Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages. To elucidate its precise role in the development of obesity and steroidogenesis, we generated HSL k...

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Detalhes bibliográficos
Main Authors: Osuga, Jun-ichi, Ishibashi, Shun, Oka, Teruaki, Yagyu, Hiroaki, Tozawa, Ryuichi, Fujimoto, Akihisa, Shionoiri, Futoshi, Yahagi, Naoya, Kraemer, Frederic B., Tsutsumi, Osamu, Yamada, Nobuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15409/
https://ncbi.nlm.nih.gov/pubmed/10639158
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