Mutations Proximal to the Minor Groove-Binding Track of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect Utilization of RNA versus DNA as Template

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), like all retroviral RTs, is a versatile DNA polymerase that can copy both RNA and DNA templates. In spite of extensive investigations into the structure-function of this enzyme, the structural basis for this dual template specif...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Fisher, Timothy S., Darden, Tom, Prasad, Vinayaka R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Assuntos:	Replication
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12719577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.10.5837-5845.2003
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