Mutations Proximal to the Minor Groove-Binding Track of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect Utilization of RNA versus DNA as Template

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), like all retroviral RTs, is a versatile DNA polymerase that can copy both RNA and DNA templates. In spite of extensive investigations into the structure-function of this enzyme, the structural basis for this dual template specif...

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Detalles Bibliográficos
Main Authors: Fisher, Timothy S., Darden, Tom, Prasad, Vinayaka R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC154037/
https://ncbi.nlm.nih.gov/pubmed/12719577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5837-5845.2003
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