Intranasal Vaccination Using Interleukin-12 and Cholera Toxin Subunit B as Adjuvants To Enhance Mucosal and Systemic Immunity to Human Immunodeficiency Virus Type 1 Glycoproteins

We have investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1 (HIV-1) isolate 89.6 by intranasal (i.n.) immunization of mice with gp120 and gp140 together with interleukin-12 (IL-12) and cholera toxin subunit B (CTB) as adjuvants. It was found that both IL-...

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Detalhes bibliográficos
Main Authors: Albu, Diana I., Jones-Trower, Agnes, Woron, Amy M., Stellrecht, Kathleen, Broder, Christopher C., Metzger, Dennis W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154022/
https://ncbi.nlm.nih.gov/pubmed/12719551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.10.5589-5597.2003
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