Intranasal Immunization with the Cholera Toxin B Subunit-Pneumococcal Surface Antigen A Fusion Protein Induces Protection against Colonization with Streptococcus pneumoniae and Has Negligible Impact on the Nasopharyngeal and Oral Microbiota of Mice

One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have h...

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Hlavní autoři: Pimenta, F. C., Miyaji, E. N., Arêas, A. P. M., Oliveira, M. L. S., de Andrade, A. L. S. S., Ho, P. L., Hollingshead, S. K., Leite, L. C. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539618/
https://ncbi.nlm.nih.gov/pubmed/16861686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00134-06
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