Intranasal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances Protection by Parenteral Mycobacterium bovis BCG Immunization against Pulmonary Tuberculosis

Parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis in humans. There is a need for developing effective boosting vaccination strategies. We examined a heterologous prime-boost regimen utilizing BCG as a prime vaccine and our re...

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Bibliographische Detailangaben
Hauptverfasser: Santosuosso, Michael, McCormick, Sarah, Zhang, Xizhong, Zganiacz, Anna, Xing, Zhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539608/
https://ncbi.nlm.nih.gov/pubmed/16861651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00517-06
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