Construction and Characterization of an Attenuated Purine Auxotroph in a Francisella tularensis Live Vaccine Strain

Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of tularemia. It is capable of escaping from the phagosome, replicating to high numbers in the cytosol, and inducing apoptosis in macrophages of a variety of hosts. F. tularensis has received significant atte...

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Bibliographic Details
Main Authors: Pechous, Roger, Celli, Jean, Penoske, Renee, Hayes, Stanley F., Frank, Dara W., Zahrt, Thomas C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539594/
https://ncbi.nlm.nih.gov/pubmed/16861631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00666-06
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