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Construction and Characterization of an Attenuated Purine Auxotroph in a Francisella tularensis Live Vaccine Strain

Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of tularemia. It is capable of escaping from the phagosome, replicating to high numbers in the cytosol, and inducing apoptosis in macrophages of a variety of hosts. F. tularensis has received significant atte...

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Библиографические подробности
Главные авторы: Pechous, Roger, Celli, Jean, Penoske, Renee, Hayes, Stanley F., Frank, Dara W., Zahrt, Thomas C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539594/
https://ncbi.nlm.nih.gov/pubmed/16861631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00666-06
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