Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination

Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way t...

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Detalhes bibliográficos
Main Authors: Ha, Sang-Jun, Park, Su-Hyung, Kim, Hye-Ju, Kim, Seung-Chul, Kang, Hyang-Ju, Lee, Eun-Gae, Kwon, Soon-Geon, Kim, Byong-Moon, Lee, Sung-Hee, Kim, Won-Bae, Sung, Young-Chul, Cho, Sang-Nae
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539587/
https://ncbi.nlm.nih.gov/pubmed/16861689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01781-05
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