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Activation of PKR by Bunyamwera Virus Is Independent of the Viral Interferon Antagonist NSs

Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated. Cellular responses to dsRNA include induction of alpha/beta interferon (IFN) synthesis and activation of the enzyme PKR, which exerts its...

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Autores principales: Streitenfeld, Hein, Boyd, Amanda, Fazakerley, John K., Bridgen, Anne, Elliott, Richard M., Weber, Friedemann
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC153953/
https://ncbi.nlm.nih.gov/pubmed/12692253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.9.5507-5511.2003
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