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A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

Apurinic/apyrimidinic (AP) sites are common DNA lesions that arise from spontaneous depurination or by base excision repair (BER) of modified bases. A biotin-containing aldehyde-reactive probe (ARP) [Kubo, K., Ide, H., Wallace, S. S. & Kow, Y. W. (1992) Biochemistry 31, 3703–3708] is used to mea...

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Detalhes bibliográficos
Main Authors: Atamna, Hani, Cheung, Ivana, Ames, Bruce N.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15391/
https://ncbi.nlm.nih.gov/pubmed/10639140
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