Decorin and TGF-β(1 )polymorphisms and development of COPD in a general population

BACKGROUND: Decorin, an extracellular matrix (ECM) proteoglycan, and TGF-β(1 )are both involved in lung ECM turnover. Decorin and TGF-β(1 )expression are decreased respectively increased in COPD lung tissue. Interestingly, they act as each other's feedback regulator. We investigated whether sin...

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Detalhes bibliográficos
Main Authors: van Diemen, Cleo C, Postma, Dirkje S, Vonk, Judith M, Bruinenberg, Marcel, Nolte, Ilja M, Boezen, H Marike
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539000/
https://ncbi.nlm.nih.gov/pubmed/16780585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-7-89
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