New Azasterols against Trypanosoma brucei: Role of 24-Sterol Methyltransferase in Inhibitor Action

A series of azasterol derivatives, designed as potential inhibitors of the Δ(24)-sterol methyltransferase enzyme (24-SMT), were synthesized and evaluated for their activities against parasitic protozoa. Values in the nanomolar range were obtained for 50% effective dose against the Trypanosoma brucei...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Gros, Ludovic, Castillo-Acosta, Victor Manuel, Jiménez, Carmen Jiménez, Sealey-Cardona, Marco, Vargas, Sofia, Manuel Estévez, Antonio, Yardley, Vanessa, Rattray, Lauren, Croft, Simon L., Ruiz-Perez, Luis M., Urbina, Julio A., Gilbert, Ian H., Pacanowska, Dolores González
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2006
Θέματα:
Mechanisms of Action: Physiological Effects
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538673/
https://ncbi.nlm.nih.gov/pubmed/16870747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01508-05
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια