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New Azasterols against Trypanosoma brucei: Role of 24-Sterol Methyltransferase in Inhibitor Action

A series of azasterol derivatives, designed as potential inhibitors of the Δ(24)-sterol methyltransferase enzyme (24-SMT), were synthesized and evaluated for their activities against parasitic protozoa. Values in the nanomolar range were obtained for 50% effective dose against the Trypanosoma brucei...

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Detalhes bibliográficos
Main Authors: Gros, Ludovic, Castillo-Acosta, Victor Manuel, Jiménez, Carmen Jiménez, Sealey-Cardona, Marco, Vargas, Sofia, Manuel Estévez, Antonio, Yardley, Vanessa, Rattray, Lauren, Croft, Simon L., Ruiz-Perez, Luis M., Urbina, Julio A., Gilbert, Ian H., Pacanowska, Dolores González
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538673/
https://ncbi.nlm.nih.gov/pubmed/16870747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01508-05
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