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New Azasterols against Trypanosoma brucei: Role of 24-Sterol Methyltransferase in Inhibitor Action
A series of azasterol derivatives, designed as potential inhibitors of the Δ(24)-sterol methyltransferase enzyme (24-SMT), were synthesized and evaluated for their activities against parasitic protozoa. Values in the nanomolar range were obtained for 50% effective dose against the Trypanosoma brucei...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1538673/ https://ncbi.nlm.nih.gov/pubmed/16870747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01508-05 |
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