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Genetic Basis for Natural and Acquired Resistance to the Diarylquinoline R207910 in Mycobacteria
The atpE gene encoding the subunit c of the ATP synthase of Mycobacterium tuberculosis, the target of the new diarylquinoline drug R207910, has been sequenced from in vitro mutants resistant to the drug. The previously reported mutation A63P and a new mutation, I66M, were found. The genetic diversit...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1538646/ https://ncbi.nlm.nih.gov/pubmed/16870785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00244-06 |
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