Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

In human disease and experimental animal models, depressed Ca(2+) handling in failing cardiomyocytes is widely attributed to impaired sarcoplasmic reticulum (SR) function. In mice, disruption of the PLN gene encoding phospholamban (PLN) or expression of dominant-negative PLN mutants enhances SR and...

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Autors principals: Haghighi, Kobra, Kolokathis, Fotis, Pater, Luke, Lynch, Roy A., Asahi, Michio, Gramolini, Anthony O., Fan, Guo-Chang, Tsiapras, Dimitris, Hahn, Harvey S., Adamopoulos, Stamatis, Liggett, Stephen B., Dorn, Gerald W., MacLennan, David H., Kremastinos, Dimitrios T., Kranias, Evangelia G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC153772/
https://ncbi.nlm.nih.gov/pubmed/12639993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317892
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