The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

Cardiac hypertrophy is a common response to pressure overload and is associated with increased mortality. Mechanical stress in the heart can result in the integrin-mediated activation of focal adhesion kinase and the subsequent recruitment of the Grb2 adapter molecule. Grb2, in turn, can activate MA...

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Main Authors: Zhang, Shaosong, Weinheimer, Carla, Courtois, Michael, Kovacs, Attila, Zhang, Cindy E., Cheng, Alec M., Wang, Yibin, Muslin, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC153766/
https://ncbi.nlm.nih.gov/pubmed/12639989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316290
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