Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity
Through direct interaction with the voltage-dependent anion channel (VDAC), proapoptotic Bcl-2 family members such as Bax and Bak induce apoptogenic mitochondrial cytochrome c release and membrane potential (Δψ) loss in isolated mitochondria. Using isolated mitochondria, we showed that Bid and Bik,...
সংরক্ষণ করুন:
| প্রকাশিত: | Proc Natl Acad Sci U S A |
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| প্রধান লেখক: | , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
National Academy of Sciences
2000
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15372/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.2.577 |
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