Abbreviated incubation times for human prions in mice expressing a chimeric mouse–human prion protein transgene

Transgenic (Tg) mouse lines that express chimeric mouse–human prion protein (PrP), designated MHu2M, are susceptible to prions from patients with sporadic Creutzfeldt–Jakob disease (sCJD). With the aim of decreasing the incubation time to fewer than 200 days, we constructed transgenes in which one o...

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Autori principali: Korth, Carsten, Kaneko, Kiyotoshi, Groth, Darlene, Heye, Norbert, Telling, Glenn, Mastrianni, James, Parchi, Piero, Gambetti, Pierluigi, Will, Robert, Ironside, James, Heinrich, Cornelia, Tremblay, Patrick, DeArmond, Stephen J., Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153633/
https://ncbi.nlm.nih.gov/pubmed/12684540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2627989100
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