The cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2) binds to and activates H-Ras

The cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) induces cell proliferation and mitogen-activated protein kinase activation. Here, we describe that these effects are mediated by 15d-PGJ(2)-elicited H-Ras activation. We demonstrate that this pathway is specific for H-Ras through t...

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Detalhes bibliográficos
Main Authors: Oliva, José Luis, Pérez-Sala, Dolores, Castrillo, Antonio, Martínez, Natalia, Cañada, F. Javier, Boscá, Lisardo, Rojas, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153631/
https://ncbi.nlm.nih.gov/pubmed/12684535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0735842100
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