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Identification of a Vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage

We identify and characterize a gene cluster in El Tor Vibrio cholerae that encodes a cytotoxic activity for HEp-2 cells in vitro. This gene cluster contains four genes and is physically linked to the cholera toxin (CTX) element in the V. cholerae genome. We demonstrate by using insertional mutagenes...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Lin, Wei, Fullner, Karla Jean, Clayton, Rebecca, Sexton, Jessica A., Rogers, Marc B., Calia, Kerstin E., Calderwood, Stephen B., Fraser, Claire, Mekalanos, John J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15352/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927695/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1071
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