Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity.

The injection of (C57BL/6 x BALB/c) F1 spleen cells into BALB/c newborn mice leads to activation of persisting F1 donor B cells and development of a lupus-like syndrome in tolerized BALB/c mice. This syndrome is characterized by hypergammaglobulinaemia, high levels of anti-DNA and anti-Sm antibodies...

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Библиографические подробности
Главные авторы: Merino, J, Schurmans, S, Wen, L, Brighouse, G, Luzuy, S, Lambert, P H
Формат: Artigo
Язык:Inglês
Опубликовано: 1990
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534764/
https://ncbi.nlm.nih.gov/pubmed/1968797
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