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T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation

The central role of type-2 helper T (Th2) cells in the development of allergic responses and immune responses against helminthic parasites is well documented. The differentiation of Th2 cells from naive T cells requires both the recognition of antigen by T cell antigen receptors (TCR) and the activa...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yamashita, Masakatsu, Kimura, Motoko, Kubo, Masato, Shimizu, Chiori, Tada, Tomio, Perlmutter, Roger M., Nakayama, Toshinori
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15344/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927687/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.3.1024
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