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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

In a screen for gene copy-number changes in mouse mammary tumors, we identified a tumor with a small 350-kb amplicon from a region that is syntenic to a much larger locus amplified in human cancers at chromosome 11q22. The mouse amplicon contains only one known gene, Yap, encoding the mammalian orth...

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Detalhes bibliográficos
Main Authors: Overholtzer, Michael, Zhang, Jianmin, Smolen, Gromoslaw A., Muir, Beth, Li, Wenmei, Sgroi, Dennis C., Deng, Chu-Xia, Brugge, Joan S., Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533802/
https://ncbi.nlm.nih.gov/pubmed/16894141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605579103
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