The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1–CR–L2) of human IR at 2.3 Å resolution and compare it wit...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Lou, Meizhen, Garrett, Thomas P. J., McKern, Neil M., Hoyne, Peter A., Epa, V. Chandana, Bentley, John D., Lovrecz, George O., Cosgrove, Leah J., Frenkel, Maurice J., Ward, Colin W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533800/
https://ncbi.nlm.nih.gov/pubmed/16894147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605395103
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares