The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1–CR–L2) of human IR at 2.3 Å resolution and compare it wit...

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Detalhes bibliográficos
Main Authors: Lou, Meizhen, Garrett, Thomas P. J., McKern, Neil M., Hoyne, Peter A., Epa, V. Chandana, Bentley, John D., Lovrecz, George O., Cosgrove, Leah J., Frenkel, Maurice J., Ward, Colin W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533800/
https://ncbi.nlm.nih.gov/pubmed/16894147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605395103
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