The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1–CR–L2) of human IR at 2.3 Å resolution and compare it wit...

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Detaylı Bibliyografya
Asıl Yazarlar: Lou, Meizhen, Garrett, Thomas P. J., McKern, Neil M., Hoyne, Peter A., Epa, V. Chandana, Bentley, John D., Lovrecz, George O., Cosgrove, Leah J., Frenkel, Maurice J., Ward, Colin W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533800/
https://ncbi.nlm.nih.gov/pubmed/16894147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605395103
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