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Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging
Inherited mutations in PARK7, the gene encoding DJ-1, are associated with loss of protein function and early-onset parkinsonism. Like human DJ-1 (hDJ-1), Drosophila DJ-1b protects against oxidative insult and is modified with oxidation. We demonstrate that hDJ-1 rescues flies mutant for DJ-1b, and t...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1533799/ https://ncbi.nlm.nih.gov/pubmed/16894167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601891103 |
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