Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

In eukaryotes, double-stranded (ds) RNA induces sequence-specific inhibition of gene expression referred to as RNA interference (RNAi). We exploited RNAi to define the role of HER2/neu in the neoplastic proliferation of human breast cancer cells. We transfected SK-BR-3, BT-474, MCF-7, and MDA-MB-468...

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Hlavní autoři: Faltus, Timo, Yuan, Juping, Zimmer, Brigitte, Krämer, Andrea, Loibl, Sibylle, Kaufmann, Manfred, Strebhardt, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2004
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1531682/
https://ncbi.nlm.nih.gov/pubmed/15720805
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