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Endosomal Dynamics of Met Determine Signaling Output

Proteasomal activity is required for Met receptor degradation after acute stimulation with hepatocyte growth factor (HGF). Inhibition of proteasomal activity with lactacystin leads to a block in the endocytic trafficking of Met such that the receptor fails to reach late endosomes/lysosomes, where de...

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Detalhes bibliográficos
Main Authors: Hammond, Dean E., Carter, Stephanie, McCullough, John, Urbé, Sylvie, Vande Woude, George, Clague, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153105/
https://ncbi.nlm.nih.gov/pubmed/12686592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-09-0578
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