The role of disulfide bonds in the assembly and function of MD-2

MD-2 is a secreted glycoprotein that binds to the extracellular domain of Toll-like receptor 4 (TLR4) and is required for the activation of TLR4 by lipopolysaccharide (LPS). The protein contains seven Cys residues and consists of a heterogeneous collection of disulfide-linked oligomers. To investiga...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Mullen, Gregory E. D., Kennedy, Margaret N., Visintin, Alberto, Mazzoni, Alessandra, Leifer, Cynthia A., Davies, David R., Segal, David M.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12642668/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0630495100
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