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Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction

Cysteine plays a key role as a metal ligand in metalloproteins. In all well-recognized cases, however, it is the anionic cysteinate that coordinates. Several cysteinate-ligated heme proteins are known, but some fail to retain thiolate ligation in the ferrous state, possibly following protonation to...

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Detalles Bibliográficos
Main Authors: Perera, Roshan, Sono, Masanori, Sigman, Jeffrey A., Pfister, Thomas D., Lu, Yi, Dawson, John H.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC152975/
https://ncbi.nlm.nih.gov/pubmed/12655049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0737142100
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