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The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin

To probe the role of copper and protons in heme-copper oxidase (HCO), we have performed kinetic studies on an engineered heme-copper center in sperm whale myoglobin (Leu-29 → His/Phe-43 → His, called Cu(B)Mb) that closely mimics the heme-copper center in HCO. In the absence of metal ions, the engine...

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Detalles Bibliográficos
Autores principales: Sigman, Jeffrey A., Kim, Hyeon K., Zhao, Xuan, Carey, James R., Lu, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC152973/
https://ncbi.nlm.nih.gov/pubmed/12655052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0737308100
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