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Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

Ornithine decarboxylase (ODC) is regulated by its metabolic products through a feedback loop that employs a second protein, antizyme 1 (AZ1). AZ1 accelerates the degradation of ODC by the proteasome. We used purified components to study the structural elements required for proteasomal recognition of...

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Bibliographic Details
Main Authors: Zhang, Mingsheng, Pickart, Cecile M., Coffino, Philip
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC152902/
https://ncbi.nlm.nih.gov/pubmed/12660156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg158
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