Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides

Gene targeting through homologous recombination in murine embryonic stem (ES) cells is already strongly suppressed by DNA mismatch-repair (MMR)-dependent anti-recombination when targeting construct and target locus differ at <1% of the nucleotide positions. We demonstrate that MMR activity also rais...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Dekker, Marleen, Brouwers, Conny, te Riele, Hein
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	NAR Methods Online
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626726/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng027
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