Glutamate at the phosphorylation site of response regulator CtrA provides essential activities without increasing DNA binding

The essential response regulator CtrA controls the Caulobacter crescentus cell cycle and phosphorylated CtrA∼P preferentially binds target DNA in vitro. The CtrA aspartate to glutamate (D51E) mutation mimics phosphorylated CtrA∼P in vivo and rescues non-viable C.crescentus cells. However, we observe...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Siam, Rania, Marczynski, Gregory T.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg271
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