3′-Exonuclease resistance of DNA oligodeoxynucleotides containing O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine

Tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a chemical carcinogen thought to be involved in the initiation of lung cancer in smokers. NNK is metabolically activated to methylating and pyridyloxobutylating species that form promutagenic adducts with DNA nucl...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Park, Soobong, Seetharaman, Mahadevan, Ogdie, Alexis, Ferguson, David, Tretyakova, Natalia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12655016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg299
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