Influence of DNA torsional rigidity on excision of 7,8-dihydro-8-oxo-2′-deoxyguanosine in the presence of opposing abasic sites by human OGG1 protein

The human protein OGG1 (hOGG1) targets the highly mutagenic base 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) and shows a high specificity for the opposite DNA base. Abasic sites can arise in DNA in close opposition to 8-oxodG either during repair of mismatched bases (i.e. 8-oxodG/A mismatches) or,...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Barone, F., Dogliotti, E., Cellai, L., Giordano, C., Bjørås, M., Mazzei, F.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12655006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg289
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