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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
BACKGROUND: Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2,...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2006
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1526740/ https://ncbi.nlm.nih.gov/pubmed/16776830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-7-49 |
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