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Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker
BACKGROUND: Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene. METHODS: Cultures were sequentially subjected to increasing doses of atovaquone alone or in combination with cycloguanil and the cytochrome b gene wa...
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Hauptverfasser: | , , , |
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Format: | Artigo |
Sprache: | Inglês |
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BioMed Central
2003
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Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152655/ https://ncbi.nlm.nih.gov/pubmed/12665429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-2-5 |
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