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Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker

BACKGROUND: Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene. METHODS: Cultures were sequentially subjected to increasing doses of atovaquone alone or in combination with cycloguanil and the cytochrome b gene wa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schwöbel, Babett, Alifrangis, Michael, Salanti, Ali, Jelinek, Tomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152655/
https://ncbi.nlm.nih.gov/pubmed/12665429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-2-5
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