Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice

We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J × CAST/Ei) F(2) cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate gene in this region. Subsequent studies with the 5LO knockout model showed effects on atheroscleros...

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Bibliografiske detaljer
Main Authors: Ghazalpour, Anatole, Wang, Xuping, Lusis, Aldons J., Mehrabian, Margarete
Format: Artigo
Sprog:Inglês
Udgivet: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526544/
https://ncbi.nlm.nih.gov/pubmed/16624897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057455
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