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Abolition of Cyclin-Dependent Kinase Inhibitor p16(Ink4a) and p21(Cip1/Waf1) Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts
Human cells are more resistant to both immortalization and malignant transformation than rodent cells. Recent studies have established the basic genetic requirements for the transformation of human cells, but much of this work relied on the expression of transforming proteins derived from DNA tumor...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC152557/ https://ncbi.nlm.nih.gov/pubmed/12665584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.8.2859-2870.2003 |
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