Abolition of Cyclin-Dependent Kinase Inhibitor p16(Ink4a) and p21(Cip1/Waf1) Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

Human cells are more resistant to both immortalization and malignant transformation than rodent cells. Recent studies have established the basic genetic requirements for the transformation of human cells, but much of this work relied on the expression of transforming proteins derived from DNA tumor...

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מידע ביבליוגרפי
Main Authors: Wei, Wenyi, Jobling, Wendy A., Chen, Wen, Hahn, William C., Sedivy, John M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2003
נושאים:
Cell Growth and Development
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC152557/
https://ncbi.nlm.nih.gov/pubmed/12665584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.8.2859-2870.2003
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