PCR-Oligonucleotide Ligation Assay for Detection of Point Mutations Associated with Quinolone Resistance in Streptococcus pneumoniae

We have developed a PCR-oligonucleotide ligation assay to rapidly identify base substitutions in topoisomerase genes that are associated with quinolone resistance in clinical isolates of Streptococcus pneumoniae. Thirty-seven strains for which the ciprofloxacin MICs were ≥4 μg/ml and 16 strains for...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Bui, Mai-Ha, Stone, Gregory G., Nilius, Angela M., Almer, Laurel, Flamm, Robert K.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Assuntos:	Mechanisms of Resistance
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1456-1459.2003
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