PCR-Oligonucleotide Ligation Assay for Detection of Point Mutations Associated with Quinolone Resistance in Streptococcus pneumoniae

We have developed a PCR-oligonucleotide ligation assay to rapidly identify base substitutions in topoisomerase genes that are associated with quinolone resistance in clinical isolates of Streptococcus pneumoniae. Thirty-seven strains for which the ciprofloxacin MICs were ≥4 μg/ml and 16 strains for...

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Bibliografiska uppgifter
Huvudupphovsmän: Bui, Mai-Ha, Stone, Gregory G., Nilius, Angela M., Almer, Laurel, Flamm, Robert K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC152482/
https://ncbi.nlm.nih.gov/pubmed/12654693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1456-1459.2003
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