Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4

HIV-1 envelope glycoproteins (Env), expressed at the cell surface, induce apoptosis of uninfected CD4(+) T cells, contributing to the development of AIDS. Here we demonstrate that, independently of HIV replication, transfected or HIV-infected cells that express Env induced autophagy and accumulation...

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Main Authors: Espert, Lucile, Denizot, Mélanie, Grimaldi, Marina, Robert-Hebmann, Véronique, Gay, Bernard, Varbanov, Mihayl, Codogno, Patrice, Biard-Piechaczyk, Martine
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523410/
https://ncbi.nlm.nih.gov/pubmed/16886061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26185
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