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Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes

The 26S proteasome contains a 19S regulatory particle that selects and unfolds ubiquitinated substrates for degradation in the 20S catalytic particle. To date there are no high-resolution structures of the 19S assembly, nor of the lid or base subcomplexes that constitute the 19S. Mass spectra of the...

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Autors principals: Sharon, Michal, Taverner, Thomas, Ambroggio, Xavier I, Deshaies, Raymond J, Robinson, Carol V
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523230/
https://ncbi.nlm.nih.gov/pubmed/16869714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040267
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