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The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

Phosphoinositide (PI) 3-kinases catalyze the phosphorylation of the D3 position of the inositol ring of PI, and its phosphorylated derivatives and play important roles in many intracellular signal transducing pathways. Class IA PI3-kinases contain distinct regulatory (p85) and catalytic (p110) subun...

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Autors principals: Fu, Zheng, Aronoff-Spencer, Eliah, Backer, Jonathan M., Gerfen, Gary J.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC152282/
https://ncbi.nlm.nih.gov/pubmed/12629217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0535975100
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