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Murine Coronavirus-Induced Hepatitis: JHM Genetic Background Eliminates A59 Spike-Determined Hepatotropism

Recombinant murine coronaviruses, differing only in the spike gene and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the background of the JHM genome, were compared for the ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice. Int...

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Autores principales: Navas, Sonia, Weiss, Susan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC152168/
https://ncbi.nlm.nih.gov/pubmed/12663803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4972-4978.2003
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