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Epstein-Barr Virus Nuclear Antigen 2 Binds via Its Methylated Arginine-Glycine Repeat to the Survival Motor Neuron Protein

Here we provide evidence that EBNA2 is methylated in vivo and that methylation of EBNA2 is a prerequisite for binding to SMN. We present SMN as a novel binding partner of EBNA2 by showing that EBNA2 colocalizes with SMN in nuclear gems and that both proteins can be coimmunoprecipitated from cellular...

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Autors principals: Barth, Stephanie, Liss, Michael, Voss, Marc D., Dobner, Thomas, Fischer, Utz, Meister, Gunter, Grässer, Friedrich A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC152127/
https://ncbi.nlm.nih.gov/pubmed/12663808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.5008-5013.2003
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