Consequences of DNA-Dependent Protein Kinase Catalytic Subunit Deficiency on Recombinant Adeno-Associated Virus Genome Circularization and Heterodimerization in Muscle Tissue

Circular concatemerization of the recombinant adeno-associated virus (rAAV) genome has been suggested as the predominant process facilitating long-term rAAV transduction in muscle. A recent study (S. Song, P. J. Laipis, K. I. Berns, and T. R. Flotte, Proc. Natl. Acad. Sci. USA 98:4084-4088, 2001) wi...

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Main Authors: Duan, Dongsheng, Yue, Yongping, Engelhardt, John F.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
主題:
Gene Therapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC152118/
https://ncbi.nlm.nih.gov/pubmed/12663782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4751-4759.2003
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