Strain Variations in Single Amino Acids of the 86-Kilodalton Human Cytomegalovirus Major Immediate-Early Protein (IE2) Affect Its Functional and Biochemical Properties: Implications of Dynamic Protein Conformation

The 86-kDa major immediate-early protein, IEP86 (IE2, IE2(579aa), or ppUL122a), from the Towne and AD169 strains of human cytomegalovirus show four amino acid variations, namely, R68Q, K455E, T541A, and seven consecutive serines beginning at position 258 in Towne and eight serines in AD169. A common...

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Pubblicato in:	J Virol
Autori principali:	Barrasa, M. Inmaculada, Harel, Noam, Yu, Yongjun, Alwine, James C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663783/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.4760-4772.2003
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