Strain Variations in Single Amino Acids of the 86-Kilodalton Human Cytomegalovirus Major Immediate-Early Protein (IE2) Affect Its Functional and Biochemical Properties: Implications of Dynamic Protein Conformation

The 86-kDa major immediate-early protein, IEP86 (IE2, IE2(579aa), or ppUL122a), from the Towne and AD169 strains of human cytomegalovirus show four amino acid variations, namely, R68Q, K455E, T541A, and seven consecutive serines beginning at position 258 in Towne and eight serines in AD169. A common...

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Hlavní autoři: Barrasa, M. Inmaculada, Harel, Noam, Yu, Yongjun, Alwine, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC152111/
https://ncbi.nlm.nih.gov/pubmed/12663783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4760-4772.2003
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