Intranasal Immunization with Recombinant Lactococcus lactis Secreting Murine Interleukin-12 Enhances Antigen-Specific Th1 Cytokine Production

Interleukin-12 (IL-12), a heterodimeric cytokine, plays an important role in cellular immunity to several bacterial, viral, and parasitic infections and has adjuvant activity when it is codelivered with DNA vaccines. IL-12 has also been used with success in cancer immunotherapy treatments. However,...

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Main Authors: Bermúdez-Humarán, Luis G., Langella, Philippe, Cortes-Perez, Naima G., Gruss, Alexandra, Tamez-Guerra, Reyes S., Oliveira, Sergio C., Cardenas, Odila Saucedo-, Montes de Oca-Luna, Roberto, Le Loir, Yves
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC152106/
https://ncbi.nlm.nih.gov/pubmed/12654805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.4.1887-1896.2003
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